Source Themes

Estimating genomic relationships of metafounders across and within breeds using maximum likelihood, pseudo-expectation–maximization maximum likelihood and increase of relationships

We derived ML, pseudo-EM and pseudo-EM+ methods to estimate in many realistic settings. Estimates are accurate in real and simulated data and have a low computational cost.

Redefining and interpreting genomic relationships of metafounders

Metafounders are a useful concept to characterize relationships within and across populations, and to help genetic evaluations because they help modelling the means and variances of unknown base population animals. Current definitions of metafounder …

Identifying BMI-associated genes via a genome-wide multi-omics integrative approach using summary data

This study integrated three types of omics data and identified a group of genes that have not previously been reported to be associated with BMI. This strategy could provide new insights for future studies to identify molecular mechanisms …

Integrated analysis of genome-wide association studies and 3D epigenomic characteristics reveal the BMP2 gene regulating loin muscle depth in Yorkshire pigs

The loin muscle depth (LMD) is positively correlated with lean meat content and can therefore be used to estimate the lean meat content of pigs. The loin muscle depth is a quantitative trait that is influenced by whole-genome distributed polygenes. …

Genomic evaluation for two-way crossbred performance in cattle

Dairy cattle production systems are mostly based on purebreds, but recently the use of crossbreeding has received increased interest. For genetic evaluations including crossbreds, several methods based on single-step genomic best linear unbiased …

Impacts of additive, dominance, and inbreeding depression effects on genomic evaluation by combining two SNP chips in Canadian Yorkshire pigs bred in China

At the beginning of genomic selection, some Chinese companies genotyped pigs with different single nucleotide polymorphism (SNP) arrays. The obtained genomic data are then combined and to do this, several imputation strategies have been developed. …

Genomic evaluation and genome-wide association studies for total number of teats in a combined American and Danish Yorkshire pig populations selected in China

Joint genomic evaluation by combining data recordings and genomic information from different pig herds and populations is of interest for pig breeding companies because the efficiency of genomic selection (GS) could be further improved. In this work, …

blupADC - An R package and shiny toolkit for comprehensive genetic data analysis in animal and plant breeding

Genetic analysis is a systematic and complex procedure in animal and plant breeding. With fast development of high-throughput genotyping techniques and algorithms, animal and plant breeding has entered into a genomic era. However, there is a lack of …

Identification of new semen trait-related candidate genes in Duroc boars through genome-wide association and weighted gene co-expression network analyses

Semen traits are crucial in commercial pig production since semen from boars is widely used in artificial insemination for both purebred and crossbred pig production. Revealing the genetic architecture of semen traits potentially promotes the …

Genome-wide association and transcriptome studies identify candidate genes and pathways for feed conversion ratio in pigs

The feed conversion ratio (FCR) is an important productive trait that greatly affects profits in the pig industry. Elucidating the genetic mechanisms underpinning FCR may promote more efficient improvement of FCR through artificial selection. In this …